Enzyme kinetics: Can the konstant KM in Michaelis-Menten model change when the model is exposed to a inhibitor, or do we use another equation to find a additional vaulue to KM?

Question

frostbite · Answer

And i mean reversible competitive inhibition .

frostbite · Answer

The Michaelis-Menten equation: $$v=\left(\begin{matrix}v_{\max} \1+\left(\begin{matrix}K_{M} \ [s]\end{matrix}\right) \end{matrix}\right)$$

trancenova · Answer

(I think you are working a little above me - but I'll give it a go anyway).

I think you would use the same equation (still MM relationship) as there is just a change in the MM constant/ maximum rate. I'm not quite sure where you are coming from, were you given some values and had to find it or something? (I've just learnt it on a theory basis).

frostbite · Answer

Found the bloody answer it is kinda mind screwing, works in theory and a I made experiment can't falsify it + A dozen of articles I found.

trancenova · Answer

Gah, sounds annoying but atleast you have the answer! :D