Question

can i make my website look totally different for mobile devices?

@Communications an…

Answer 1

<link rel="stylesheet" href="mobile.css" media="handheld" />
You can do media="only screen and (max-device width:450px) too for specific size, I think...
media="screen" is for desktops so as you guess for "handheld" = mobile devices

Answer 2

Yes you can, Use HTML or jQtouch.

Answer 3

Indeed. There are a variety of ways. One good approach is called responsive web design. Look it up, there are a lot of budding materials in this area.