Question

What makes HIV to escape from all therapeutic approaches?

Answer 1

Simply put, it attacks the immune system, so it weakens our ability to fully take advantage of therapies. It also has a very high replication rate, which allows it to mutate and quickly become resistant to drugs.
So it weakens us, making shock therapy less effective (because of the risks of death), and it mutates quickly, making drugs less effective or useless.

Answer 2

perfect

Mutation rate is very high, but is also cost for low infectibility by progeny of HIV
And HIV alone can never kill a human he needs other disease to kill human