Can yeast be used in Enzyme therapy for the disease Phenylketonuria (PKU)?

Question

anonymous · Answer

If by enzyme therapy you mean giving someone the proper enzyme to correct for the disease, then sure.  Yeast are eukaryotes and therefore undergo eukaryotic transcription/translation (although in a slightly different means than humans), so this means they have the machinery and such to properly fold up an enzyme.  

Using bacteria would be either risky/not worth it since they don't have the machinery capable of properly folding the translated enzyme.