Question

1. For each polypeptide sequence listed, choose from the options given below to indicate which
secondary structure the sequence is most likely to form upon folding. The nonpolar amino acids
are italicized. Explain your choice(s).

A. Leu-Gly-Val-Leu-Ser-Leu-Phe-Ser-Gly-Leu-Met-Trp-Phe-Phe-Trp-Ile
B. Leu-Leu-Gln-Ser-Ile-Ala-Ser-Val-Leu-Gln-Ser-Leu-Leu-Cys-Ala-Ile
C. Thr-Leu-Asn-Ile-Ser-Phe-Gln-Met-Glu-Leu-Asp-Val-Ser-Ile-Arg-Trp

amphipathic α helix hydrophilic α helix
hydrophobic α helix amphipathic β sheet
hydrophilic β sheet