BRCA1 mutation

BRCA2 mutation

No BRCA mutation

Total

Number of patients

89

35

318

442

Average age at diagnosis

43.9

46.2

50.4

Preventative mastectomy*

6

3

14

23

Preventative oophorectomy*

38

7

22

67

Number of deaths

16

1

21

38

Percent died

18

2.8

6.9

8.6

*A mastectomy is the surgical removal of one or both breasts, either partially of fully. An oophorectomy is the surgical removal of an ovary or ovaries.

Question

BRCA1 mutation
	

BRCA2 mutation
	

No BRCA mutation
	

Total

Number of patients
	

89
	

35
	

318
	

442

Average age at diagnosis
	

43.9
	

46.2
	

50.4
	

 

Preventative mastectomy*
	

6
	

3
	

14
	

23

Preventative oophorectomy*
	

38
	

7
	

22
	

67

Number of deaths
	

16
	

1
	

21
	

38

Percent died
	

18
	

2.8
	

6.9
	

8.6

*A mastectomy is the surgical removal of one or both breasts, either partially of fully. An oophorectomy is the surgical removal of an ovary or ovaries.

anonymous · Answer

BRCA1 mutation
	

BRCA2 mutation
	

No BRCA mutation
	

Total

Number of patients
	

89
	

35
	

318
	

442

Average age at diagnosis
	

43.9
	

46.2
	

50.4
	

 

Preventative mastectomy*
	

6
	

3
	

14
	

23

Preventative oophorectomy*
	

38
	

7
	

22
	

67

Number of deaths
	

16
	

1
	

21
	

38

Percent died
	

18
	

2.8
	

6.9
	

8.6

*A mastectomy is the surgical removal of one or both breasts, either partially of fully. An oophorectomy is the surgical removal of an ovary or ovaries.

Things to address in your summary essay:

    Describe how mutations lead to genetic variations.
    Which appears to be more dangerous: the BRC1 or BRC2 mutation?
    Analyze a woman’s risk of dying of cancer if she carries a mutated BRC1 gene.
    How do heredity and inheritance relate to the data presented in these charts?
    What data would you need to see in order to draw conclusions about the effectiveness of preventive surgeries?
    What does the age at diagnosis tell you about the mutation?
    Explain how breast-cancer genes are still present in the population, despite cancer-related surgeries and deaths.

anonymous · Answer

HELP PLEASE!!!

aaronq · Answer

you need help with?

anonymous · Answer

yes. im stuck on it and i have to do it quickly to get my flvs done.

aaronq · Answer

which part are you stuck on?

anonymous · Answer

the whole thing... i have the chart but this is what it wants me to do



Describe how mutations lead to genetic variations. Which appears to be more dangerous: the BRC1 or BRC2 mutation? Analyze a woman’s risk of dying of cancer if she carries a mutated BRC1 gene. How do heredity and inheritance relate to the data presented in these charts? What data would you need to see in order to draw conclusions about the effectiveness of preventive surgeries? What does the age at diagnosis tell you about the mutation? Explain how breast-cancer genes are still present in the population, despite cancer-related surgeries and deaths.

anonymous · Answer

BRCA1 mutation	BRCA2 mutation	No BRCA mutation	Total
Number of patients	89	35	318	442
Average age at diagnosis	43.9	46.2	50.4	 
Preventative mastectomy*	6	3	14	23
Preventative oophorectomy*	38	7	22	67
Number of deaths	16	1	21	38
Percent died	18	2.8	6.9	8.6

aaronq · Answer

you need to do some research yourself first, i mean the first question you can basically google. 

the second, just compare the data and see which percentage has the higher mortality rate

the third, just see what the percentage of deaths for the BRC1 mutation there were in the study

etc

anonymous · Answer

ok. thanks

aaronq · Answer

no problem, good luck.