1. For each polypeptide sequence listed, choose from the options given below to indicate which
secondary structure the sequence is most likely to form upon folding. The nonpolar amino acids
are italicized. Explain your choice(s).

A. Leu-Gly-Val-Leu-Ser-Leu-Phe-Ser-Gly-Leu-Met-Trp-Phe-Phe-Trp-Ile
B. Leu-Leu-Gln-Ser-Ile-Ala-Ser-Val-Leu-Gln-Ser-Leu-Leu-Cys-Ala-Ile
C. Thr-Leu-Asn-Ile-Ser-Phe-Gln-Met-Glu-Leu-Asp-Val-Ser-Ile-Arg-Trp

amphipathic α helix hydrophilic α helix
hydrophobic α helix amphipathic β sheet
hydrophilic β sheet

Question

1. For each polypeptide sequence listed, choose from the options given below to indicate which
secondary structure the sequence is most likely to form upon folding. The nonpolar amino acids
are italicized. Explain your choice(s).

A.	Leu-Gly-Val-Leu-Ser-Leu-Phe-Ser-Gly-Leu-Met-Trp-Phe-Phe-Trp-Ile
B.	Leu-Leu-Gln-Ser-Ile-Ala-Ser-Val-Leu-Gln-Ser-Leu-Leu-Cys-Ala-Ile
C.	Thr-Leu-Asn-Ile-Ser-Phe-Gln-Met-Glu-Leu-Asp-Val-Ser-Ile-Arg-Trp

amphipathic α helix   	hydrophilic α helix
hydrophobic α helix   	amphipathic β sheet
hydrophilic β sheet

aaronq · Answer

Start by determining whether or not the amino acids are hydrophobic or hydrophilic. What characteristics makes a $\beta$ sheet and an $\alpha$ helix have it's shape?