Question

Knockout mice that are unable to produce caspase -9 die as a result of a number of defects, most notably a greatly enlarged brain. Why would these mice have this phenotype? How would you expect the phenotype of a cytochrome c knockout mice to compare with that of the caspase-9 knockout?

Answer 1

because leaking of cytochrome c from mitochondria acts as a signal for the caspases to get activated and in turn the apoptosis is turned on...