Question

Good morning :) please help .
Why are these lines from Act III important in the plot of the play?

Macbeth to Lady Macbeth

the time has been,
That, when the brains were out, the man would die,
And there an end; but now they rise again,
With twenty mortal murders on their crowns,
And push us from our stools: this is more strange
Than such a murder is