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Which of the following relationships has the closest DNA match? husband - wife mother - child father - child brother - sister
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On average, mother - child. They share half the genome and additionally, the mitochondrial / cytoplasmic inheritance. You can imagine a situation in which a brother and sister share everything except the Y chromosome and one X chromosome. This would be possible but VERY unlikely. On average, brother and sister would share half their chromosomes (I'm not considering crossover here), but could share more, or less.
Mother and child is the best answer
mother +child
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