Question

Read the sentence.

Ted Kennedy fought a brain tumor for over a year however he died on August 25, 2009.

Which is the best way to correctly punctuate this sentence?


Ted Kennedy fought a brain tumor for over a year, however, he died on August 25, 2009.
Ted Kennedy fought a brain tumor for over a year; however, he died on August 25, 2009.
Ted Kennedy fought a brain tumor for over a year: however, he died on August 25, 2009.
Ted Kennedy fought a brain tumor for over a year however, he died on August 25, 2009.