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Why does the enzyme pepsin (present in the stomach) denature in the intestine? The enzyme denatures due to change in temperature as it enters the intestine. The enzyme denatures due to the alkaline environment of the intestine. The enzyme denatures due to lack of substrate molecules in the intestine.
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@Abhisar
The enzyme denatures due to the alkaline environment of the intestine.
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Pepsin is most active in acidic environments between 37 °C and 42 °C. Accordingly, its primary site of synthesis and activity is in the stomach (pH 1.5 to 2). Pepsin exhibits maximal activity at pH 2.0 and is inactive at pH 6.5 and above that is in intestine
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