Question

what is the medication error for PO Mefenamic acid [ponstan] 500mg TDS ?

Answer 1

Generice Name: Mefenamic Acid
Brand Name:Ponstan, Ponstel
Classifications:central nervous system agent; analgesic; nsaid; antipyretic
Pregnancy Category:C

Availability
250 mg tablets

Actions
Anthranilic acid derivative. Like ibuprofen inhibits prostaglandin synthesis and affects platelet function. No evidence that it is superior to aspirin.

Therapeutic effects
Analgesic, antiinflammatory, and antipyretic actions similar to those of ibuprofen.

Uses
Short-term relief of mild to moderate pain including primary dysmenorrhea.

Contraindications
Hypersensitivity to drug;GI inflammation,or ulceration.Safety in children <14 y, during pregnancy (category C), or lactation is not established.

Cautious use
History of kidney or liver disease;blood dyscrasias;asthma;diabetes mellitus;hypersensitivity to aspirin. Long term use increases risk of serious adverse events.

Route & Dosage

Mild to Moderate Pain
adult: PO Loading Dose 500 mg
PO Maintenance Dose 250 mg q6h prn

Administration

Oral

Give with meals, food, or milk to minimize GI adverse effects.
Do not use drug for a period exceeding 1 wk (manufacturer’s warning).

Adverse effects
CNS:Drowsiness, insomnia, dizziness, nervousness, confusion, headache.
GI:Severe diarrhea, ulceration, and bleeding; nausea, vomiting, abdominal cramps, flatus, constipation, hepatic toxicity.
Hematologic:Prolonged prothrombin time, severe autoimmune hemolytic anemia (long-term use), leukopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura, megaloblastic anemia, pancytopenia, bone marrow hypoplasia.
Urogenital:Nephrotoxicity, dysuria, albuminuria, hematuria, elevation of BUN.
Skin:Urticaria, rash, facial edema.
SpecSenses:Eye irritation, loss of color vision (reversible), blurred vision, ear pain.
BodyWhole:Perspiration.
CV:Palpitation.
Respiratory:Dyspnea; acute exacerbation of asthma; bronchoconstriction (in patients sensitive to aspirin).
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