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How did American Indians react to American settlers in the late 1700s and early 1800s? A-Most American Indians lived west of the Appalachians, so settlement had little effect on them. B-Settlement affected American Indians very little, but they resented the arrival of explorers. C-The two groups were trading partners, so both sides lived in peaceful coexistence. D-American settlers and American Indians often clashed as settlement spread across the West during that era.
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it should be D
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