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There's an interesting compromise between sickle cell anaemia and malaria. One gene that causes sickle cell can also give resistance to malaria. Heterozygous individuals get the best of both worlds. peanut allergy is another adaptation that could shorten life. As for fecundity; the shape of the pelvis would lead to easier or complicated childbirth. Sperm count, for the men, and a midwife told me that in the days when women spent more time on their hands and knees, scrubbing floors, there were far fewer cesaerian sections needed. So there's a socio-environmental factor.
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