What technique could scientists use to determine the location of the disease gene in the human genome?

1. RNAi
2. use microarray to compare mRNA levels in normal and diseased individuals
3. use microarray to compare SNP profiles of family members from the pedigree
4. cloning by complementation
5. cloning by protein expression

Question

What technique could scientists use to determine the location of the disease gene in the human genome?

1. RNAi 
2. use microarray to compare mRNA levels in normal and diseased individuals 
3. use microarray to compare SNP profiles of family members from the pedigree 
4. cloning by complementation 
5. cloning by protein expression

shrutipande9 · Answer

What geneticist use these days is an SNP. ie single nucleotide polymorphisim. http://en.m.wikipedia.org/wiki/Single-nucleotide_polymorphism

anonymous · Answer

scientists could use data on recombination frequencies to determine the distance between the two genes. This ability to map genes to specific human chromosomes and to define chromosomal gene neighborhoods provided an invaluable platform for the launch of the Human Genome Project and for mapping disease genes.

anonymous · Answer

See the choices above.

nincompoop · Answer

gene mapping, SNP and microarray help scientist to help detect the location of the disease http://www.nature.com/scitable/topicpage/gene-mapping-and-disease-34600 http://www.nature.com/scitable/topicpage/rare-genetic-disorders-learning-about-genetic-disease-979