Question

You want to study the effects on the organism of high circulating levels of LDL using a mouse model. Which one of the following tools would be best to use in your studies?
a) add an extra copy of the HMG CoA reductase gene fused to the GFP coding sequence
b)add an extra copy of the LDL receptor gene fused to the GFP coding sequence
c)create a mouse where the gene encoding the HMG CoA reductase has been knocked out d)create a mouse where the gene encoding the LDL receptor has been knocked out
e)add an extra copy of the gene encoding LDL receptor

Answer 1

@nincompoop

Answer 2

someone told me to "add an extra copy of the LDL receptor gene fused to the GFP coding sequence" but i dont know.

Answer 3

can u help @nincompoop

Answer 4

@thomaster @nincompoop

Answer 5

can u elaborate @nincompoop

Answer 6

that shouldn't be a bad option right? add a copy

Answer 7

i dont know, should it?

Answer 8

yeah
you want an increased effect so you always add or disable what inhibits it

Answer 9

so that means i don't create any mouse, right?

Answer 10

do i add an extra copy of the LDL receptor gene fused to the GFP coding sequence?

Answer 11

@nincompoop

Answer 12

is it correct?

Answer 13

@nincompoop

Answer 14

@nincompoop it was wrong

Answer 15

then try A or E

Answer 16

e is the correct one

Answer 17

exactly
http://www.pnas.org/content/95/8/4544.full.pdf

Answer 18

I don't think you've been reading your book