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OpenStudy (justuu):

Where are most of the largest Midwestern cities located? Great Lakes great plains central plains Mississippi River

OpenStudy (nurali):

Chicago is the most populated city in the American Midwest and the third most populous in the entire country. Other large Midwest cities include (in order by population): Indianapolis, Columbus, Detroit, Milwaukee, Kansas City, Omaha, Minneapolis, Cleveland, Wichita and St. Louis.

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