Question

The equation, E= mc2, is usually used for nuclear reactions and not for chemical reactions, because:

the amount of energy released in nuclear reactions is so much larger than the energy released in chemical reactions

the amount of energy released in nuclear reactions is so much smaller than the energy released in chemical reactions

the amount of energy released in nuclear and chemical reactions is about the same, but Einstein only measured nuclear reaction energies

Einstein derived the equation after nuclear reactions were well-known