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Vocaloid:
Microbiology Question - why is a low-molecular weight desirable for antibiotic synthesis?
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JustSaiyan:
I would say it is because some bacteria are resistant to quite a few different high-molecular-weight antibiotics from the low permeability of its outer membrane, shielding it. However, it could also be that low-weight antibiotics are just easier to extract and purify for use.
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