Question

During Mitosis, what makes the nuclear membrane disintegrates? During Mitosis, what makes the nuclear membrane disintegrates? @Biology

Answer 1

This is the best I could come up with so far...

The Nuclear Envelope Is Disassembled During Mitosis10

The nuclear lamina is a meshwork of interconnected protein subunits called nuclear lamins. These are a special class of intermediate filament proteins (discussed in Chapter 16) that polymerize into a two-dimensional lattice (Figure 12-17). The nuclear lamina is thought to give shape and stability to the nuclear envelope, to which it is anchored by attachment to both the nuclear pore complexes and the inner nuclear membrane. As the chromatin is also thought to interact directly with the nuclear lamina, the lamina provides a structural link between the DNA and the nuclear envelope.
When a nucleus disassembles during mitosis, the nuclear lamina depolymerizes, at least partly as a consequence of the phosphorylation of the nuclear lamins at the onset of mitosis. At the same time the nuclear pore complexes disassemble into their various components. Depolymerization of the nuclear lamina is probably a prerequisite for the nuclear envelope to break up into membrane vesicles, which, together with the nuclear contents, disperse throughout the cytosol...
http://ce.et.tudelft.nl/~christos/downloads/MBotC/www.ncbi.nlm.nih.gov/books/mboc/mboc.cgi @code=1202051500099210.htm