Question

in relevance to anaphase. if a mutation inactivated securin so that it could not bind to seperase, what would be the likely consequence to the daughter cells?

Answer 1

I imagine the lack of securin would lead to separate activity at the wrong point in the cell cycle, so perhaps the sister chromatids wouldn't be bound together. I imagine the daughter cells would get a random selection of chromosomes and die off fairly quickly. The only thing about this question is that the spontaneous mutation in securin would be lethal to the cells and hence unlikely to appear. I guess I mean it's probably just a hypothetical question to make sure you get the idea that securin binds the protease called separase which in turn digests cohesion, which holds the sister chromatids together at anaphase.

Answer 2

Highlighting, as usual, the need for different buttons for 'good answer' and 'bloody good answer.'