Question

Mechanism of action of Aspirin?

Answer 1

Blocks COX 1 n 2 irreversibly (covalently), thus preventing Prostaglandin synthesis

Answer 2

Low doses (typically 75 to 81 mg/day) are sufficient to irreversibly acetylate serine 530 of cyclooxygenase (COX)-1. This effect inhibits platelet generation of thromboxane A2, resulting in an antithrombotic effect.
Intermediate doses (650 mg to 4 g/day) inhibit cyclooxygenase (COX)-1 and COX-2, blocking prostaglandin (PG) production, and have analgesic and antipyretic effects.
High doses (between 4 and 8 g/day) are effective as antiinflammatory agents in rheumatic disorders; the mechanism(s) of action at these high doses may include both PG-dependent (particularly COX-2 dependent PGE2) and independent effects [1]. However, the usefulness of aspirin at these high doses is limited by toxicity, including tinnitus, hearing loss, and gastric intoleranc

Answer 3

thats awesome, where did you learnt this?

Answer 4

learn*

Answer 5

google ....

Answer 6

lol true

Answer 7

So the main thing to remember is that Cyclo oxygenase 1 and 2 are inhibited by it, which in turn inhibits the production of prostagalndins, which leads to anti thrombotic effects.. Got it

Answer 8

Thanks aaronq and shawn

Answer 9

no prob ! yeah also anti inflammatory, antipyretic (antifever)