what problem occurs with DNA replication that Okazaki fragments are needed to complete the process? what problem occurs with DNA replication that Okazaki fragments are needed to complete the process? @Biology
well, you know that there are two DNA strands, right? and they are "facing" in opposite directions. DNA is replicated 5'-3', always. reason for that is that the nucleobases that are built in come as triphosphates, which have to stick out after the base has been added to the strand. else, if you make a synthesizing mistake, you can't correct it. that being said, you have to synthesize two different strands simultaneously, with one enzyme (!), in two different directions. this is a sheer positioning problem. that's why the "leading strand" is synthesized in one sitting, whereas the "lagging strand" will be built in many smaller fragments, the so-called okazaki-fragments.
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