What key organelles, when damaged, cause the cell to go through apoptosis (in addition to the genetic information in the nucleus)?

Question

tetyana · Answer

I would assume that the mitochondrion is one of them. Can this be confirmed or denied? Can you guys confirm some others?

anonymous · Answer

Yes, it's the mitochondria. Release of cytochrome C.

anonymous · Answer

The Cytochrome complex, or cyt c is a small heme protein found loosely associated with the inner membrane of the mitochondrion. It belongs to the cytochrome c family of proteins. Cytochrome c is a highly soluble protein, unlike other cytochromes, with a solubility of about 100 g/L and is an essential component of the electron transport chain, where it carries one electron. It is capable of undergoing oxidation and reduction, but does not bind oxygen. It transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). In humans, cytochrome c is encoded by the CYCS gene.[1][2] http://en.wikipedia.org/wiki/Cytochrome_c