Question

what is the need of INTRON DNA sequence?

Answer 1

really until now, anyone have the really respond. But is more accept that introns permit that sequence of RNAm give differents final effect. Yeah but you never forget that introns are information too.

Answer 2

what exactly do they code for? it looks like a random and useless piece of nucleotides in the DNA/RNA. they get cut out anyway by spliceosomes, so what are they for?

Answer 3

Introns are essential for ALTERNATIVE SPLICING.

Answer 4

Introns also helpful to protect coding area from the activity of transposon. Even in yeast, introns are expressed. I have an imaginary experiment to insert human's intron sequence into bacteria and see what will happen next.

Answer 5

tell us about it when you get a result! it sounds really interesting!

Answer 6

Very interesting indeed. But since i still looking for theoretical explanation, i did the experiment based on bioinformatics analysis. Hopefully it could leads us to a new kind of polypeptides molecule or something...

Answer 7

As noted above, introns are essential for alternate splicing.

In general, the non-coding regions of DNA including introns were one of the big surprises of the human genome project and remain incompletely understood today. Some research into so called "inteins" or self-excising and possibly catalytic introns is very intriguing. As is research into the possible regulatory roles of the intron RNAs once they are spliced out of the coding mRNA molecules.

Answer 8

Actually, according to the mechanism of mutation on DNA which cause cancer cells, one of the role of introns on DNA is preventation of Exons against mutation, which is done by splicing

Answer 9

Hamid, I am interested in how introns prevent mutations in exons! Do you have a review or an article I could read on the subject?

Answer 10

Dear blues,
Actually, you can find about it in this book : Principle of Cancer Genetics by Fred Banz.
In this book, chapter 1, 2 and 3 is about different types of mutation on INTRON and EXONS on DNA and RNA, and role of INTRONS, role of Hot Spot in DNA ( CpG) and more........
I think it can be very helpful for you my friend.