Question

Does anyone know what the primary mechanism(s) for PLA (polylactic acid) and PEG (polyethylene glycol) renal clearance in vivo are?

Answer 1

Can't say I am familiar with this. Maybe the other dude might know: frosty.

Answer 2

:(

Answer 3

:S thanks anyways @abb0t

Answer 4

Because if this question does get answered, I can get an alert and find out about this.

Plus, Clara, why are you being nosy in a question that I know for a fact you can't answer. You couldn't even answer a basic biology question. Swerve.

Answer 5

I talked to someone from my lab and finally got an answer, so in case you were wondering @abb0t, PLA and PEG co-polymers are hydrolysed and enter the tricarboxylic acid pathway and are removed through renal filtration.

Hak, CS; et al. Renal Clearance of Nanoparticles, Nat Biotechnol. 2007, 10, 1165-1170

Xiao, R; et al. Recent advances in PEG–PLA block copolymer nanoparticles. Int J Nanomedicine. 2010; 5: 1057–1065.

you can check these articles for further explanation

Answer 6

Nice! Thanks for that sourcing! I'll look it up when I get home.
By the way, what's the word that is used to describe when all bond-making and bond-breaking events happen simultaneously?