I have a question about the reaction mechanism shown in this diagram: http://en.wikibooks.org/wiki/Biochemistry/Peptide_Bond_Formation

I'm aware that forming a peptide from amino acids results in the loss of a water. Where does that part come in to the reaction?

Question

I have a question about the reaction mechanism shown in this diagram: http://en.wikibooks.org/wiki/Biochemistry/Peptide_Bond_Formation

I'm aware that forming a peptide from amino acids results in the loss of a water. Where does that part come in to the reaction?

abb0t · Answer

What part? the dehydration part?

abb0t · Answer

are you referring to a transaminase reaction?

anonymous · Answer

Yes, it's not shown in the diagram because the amino acid started off as a zwitterion to begin with, so the H from the -COOH is already part of the -NH2 group. I'm just confused as to how the water forms now since the catalyst has already broken off.

anonymous · Answer

The dehydration part.

abb0t · Answer

well, from what i can see, basically what's happening is that ATP is the driving force for this reaction here, but|dw:1393472965999:dw|