Question

Under what circumstances would you expect to find a “slow” enzyme in living systems?

I'm thinking maybe some processes that aren't highly regulated.. but i can't find any examples except alkaline phosphatase

Answer 1

what do u mean by slow enzyme??? as in its activity is less? rate of reaction is less? something like dat?

Answer 2

yeah, like a those with a low turnover number \((k_{cat})\)

Answer 3

ahh yes.give me sometime...i can find that for u

Answer 4

thanks, even an example or two that would be awesome.

Answer 5

i know 1 example which i studied...i think it would fit here....the cyclin dependent kinases become partially active(as in low turnover no) when cyclin binds to it. binding of cyclin causes conformational change which then leads to dephosphorylation of the enzyme..and it becomes completely active later...so at d initial stages kcat is very low

Answer 6

i hope this helps

Answer 7

okay great! I'm gonna look into it a bit more. Thanks a lot, i appreciate it !

Answer 8

ur welcome..:D

Answer 9

http://www.pearsonhighered.com/mathews/ch11/ta11p1.htm