Hemophilia is a gender-linked blood disorder in humans. The gene responsible for it is gene-linked recessive, meaning it is present on the X chromosome. When the gene is present in males (Xh), it always expresses itself, meaning that the male's blood won't clot properly. When present in females in a heterozygous condition (XhXH), the gene doesn’t express itself; but the female becomes a carrier, meaning that her offspring could have hemophilia.. When present in a homozygous recessive condition in females (XhXh), it expresses itself.

One of every 10,000 persons is affected by this disease.

Question

Hemophilia is a gender-linked blood disorder in humans. The gene responsible for it is gene-linked recessive, meaning it is present on the X chromosome. When the gene is present in males (Xh), it always expresses itself, meaning that the male's blood won't clot properly. When present in females in a heterozygous condition (XhXH), the gene doesn’t express itself; but the female becomes a carrier, meaning that her offspring could have hemophilia.. When present in a homozygous recessive condition in females (XhXh), it expresses itself.

One of every 10,000 persons is affected by this disease.

anonymous · Answer

What could be the allele frequency for this disease in the entire population?

blues · Answer

You want to use the Castle-Hardy-Weinburg Equation:

1 = p^2 + 2pq + q^2

Where p is the frequency of the dominant (i.e., normal) allele. And q is the frequency of the disease allele. Let me know if you'd like further help. :)