Question

Pattern recognition receptors are developed by -
a)Host organism b)Pathogen c) Infected tissue
d)T-cell.

Answer 1

What do u think should be the answer ?

Answer 2

c

Answer 3

Bingo !!
u r crrct

Answer 4

u want me to explain it ?

Answer 5

Wait......!!

Answer 6

Yeah...its ok

Answer 7

ok why cant it be T cells ?

Answer 8

No,I know the explanation ,just wanted to confirm the answer.Thanks.

Answer 9

I think it will be T cells

Answer 10

Because it comes under adaptive immunity,but pattern recognition receptors are developed by innate immunity.

Answer 11

ok what about gamma/delta T cells ?

Answer 12

I agree with u but various subsets may also be considered part of the innate immune system ?

Answer 13

But its not specified here about what type of T-cells.

Answer 14

Hmmmm...I see

Answer 15

@mrdoldum

Answer 16

I think infected cells produce DAMP

Answer 17

@nincompoop

Answer 18

@anonymous_user

Answer 19

@Abhisar Well, I'm reading up on it now, it has been a bit too long since my human physiology studies. It seems a bit confusing though; like all work on human genes and the like, as we are increasing our knowledge we realize these things are not actually black and white.

Answer 20

yaaah u r ryt :D,
Ok so should i wait for u to reply ?

Answer 21

@Abhisar Yeah, I will be reading in a different tab so I will not see this page.

Answer 22

roger that sir !!

Answer 23

she is right...what help do u want from me abhisar?

Answer 24

@shrutipande9 u sure it would be infected cells and not the T cells ?

Answer 25

@Abhisar Okay, it looks like the main portion, despite the new evidence that has increased the range, of pattern recognition receptors are expressed by macrophage and other cells (including Kupffer cells) in inflamed tissue.

Answer 26

So it would be infected tissue ?

Answer 27

Answer can be A also.Isnt it ?

Answer 28

or rather it would only be A ?

Answer 29

Well, here is the thing, it is expressed by the immune system cells in the inflamed tissue so that the organism causing the inflammation can be specifically targeted.

Answer 30

@Abhisar Most of these cells are in all tissue (usually the microphages) and wait to react.

Answer 31

ok sir

Answer 32

according to what i have read.... http://www.ncbi.nlm.nih.gov/pubmed/22041420
see dis...

Answer 33

@Abhisar @shrutipande9 Yes, that pub shows part of the issue. It appears that PRR is expressed in some Tcells.

Answer 34

So what should be the correct option accrdng to u ?
@mrdoldum

Answer 35

@Abhisar I think the "developed by" bit might be more meant to be "expressed", so, C. This is getting to the fact that the PRR are expressed mostly in response ti inflammation. Sorry, only have one hand to type.

Answer 36

I see..!!
One last thing can i say that PRR are expressed in response of infected tissue and mediated by T cells ?

Answer 37

Gamma delta T cells to be more specific

Answer 38

@Abhisar one min.

Answer 39

@Abhisar Well, I cant tell for sure it T-cells express them or are just involved by recognizing the other immune cells that help them ID the pathogens and do express the PRR.

Answer 40

Hmmmm..
Thank you very much for taking the pain sir. U hv certainly always been my life saver..!!

Answer 41

@Abhisar If I was at work I could get the publications and get a much more detail. I might be there tomorrow and read up on it. Well, I'll do that anyway because I'm interested in it,

Answer 42

Wow that would be so nice sir !!

Answer 43

I'll wait for ur next response then

Answer 44

@Abhisar I think I left my human physiology book at work as well. In fact, all my books are there: genetics, cell and molecular biology, and biochemistry. Oh, I may have a electronic copy of a immunology book. I'll check.

Answer 45

Ohkay sir

Answer 46

I got it sir

Answer 47

The anti microbial activity is mediated by interferons

Answer 48

Basically whenever a pathogen infects a cell its pathogen-associated molecular patterns binds with PRR and induces secretion of interferons

Answer 49

These are innate and non specific immunity

Answer 50

These PRRs like Toll like receptors or the cytoplasmic receptors RIG-I or MDA5 are found in every cells

Answer 51

These interferons further protect other surrounding cells from being damaged by the pathogen

Answer 52

However still dont know the role of Gamma Delta T cells

Answer 53

Thanks everyone for helping me out with this.

Answer 54

Anytime !