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Hypoxia has many different causes, but the bottom line is that metabolism in the cells of the body receive too little oxygen to function normally. Various basic causes of tissue hypoxia are shown by the list below: Hypoxic hypoxia. The body functions normally, but the concentration of oxygen in the inspired air is low enought to cause tiisue hypoxia because too little oxygen enters the blood. Pulmonary hypoxia. Lung function is so abnormal due to disease or injury that insufficient oxygen is transferred from inspired air into the blood. Anemic hypoxia. The amount of oxygen carried by a given volume of blood is directly related to the concentration of hemoglobin in the blood. If the hemoglobin concentration is toos low, insufficient oxygen is transported to the cells of the body to sustaing normal tissue function, and tissue hypoxia occurs (see page on anemia for a more extensive discussion of anemia). Stagnant hypoxia. This is tissue hypoxia occurring when blood flow to a part of the body, or all the body, is restricted due to disease or injury. The end result is that tissue hypoxia occurs due to a low flow of blood through the tissue, even though the blood may have a normal, or even higher than normal oxygen content. Stagnant hypoxia of the whole body occurs due to heart failure, cardiogenic shock, or during cardiac massage. These are typical situations where blood flow to the whole body is reduced. Stagnant hypoxia to specific body parts classically occurs due to a tourniquet, injury, or arterial disease. Cellular hypoxia. More than sufficient oxygen is delivered to the cells of body tissues to sustain normal function. However, poisoning of cellular metabolism by various poisons such as cyanide means the cells cannot use the oxygen. Failure of vital metabolic pathways utilizing oxygen to produce the energy generating molecules needed to sustain normal cellular function results in hypoxic failure of tissue function.
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