how the functioning of enzymes can be affected by changes in temprature ,including changes due to changes in active site

Question

anonymous · Answer

How do you a machine is working or as being over used

anonymous · Answer

Okay let me explain that for you
What is a catalyst? It undergoes no chemical changes and increases the rate of reaction
 So therefore, for you to increase the rate of reaction u need heat. Now back to your question. Enzymes are catalyst and their changes in temperature is caused by Kinetic energy.

hectoroftroy · Answer

Temperature scales entropic changes. Think about Delta G = Delta H - T*DeltaS.

At higher temperatures the protein is more disordered - it has more conformational fluidity. It needs some ability to shift conformation to work - think about the changes it must undergo to catalyse reactions. But too much ability to shift conformation and it loses the specificity of shape it needs to catalyse reactions.

anonymous · Answer

Enzymes are held together by different types of bond. At high temperatures, these bonds will break as the molecules vibrate too much. Therefore, this will change the active site as the active site is of a specific shape made by the interaction between the bonds. As the active site changes, the substrate (the thing that fits into the active site) no longer fits and the enzyme is said to be denatured. Thus, doesn't work at high temperatures.