Question

Can the base Guanine pair with the base Uracil?
How about the base Adenine with Guanine?
keyword: base-pairing, molecular biology

Answer 1

I know for a fact that adenine will not bond with guanine, as adenine will only form a hydrogen bond/complementary base pair with thymine.

Answer 2

A guanine and uracil pair is a well-known Wobble base pair. Not 100% sure if that would be an acceptable answer. Guanine-Uracil pairing is unnatural, but possible.

Answer 3

Ahh, I didn't even think about that before I typed. No sarcasm, thank you for correcting me. Just learned something new.

Answer 4

http://www.rna.icmb.utexas.edu/SIM/4D/Diatom_Shape/FIG/Fig1.pdf

http://www.ncbi.nlm.nih.gov/pubmed/15040452

Answer 5

if UG is possible then AG is also possible
The key about non-Watson-Crick base pairing is that if Purine is paired with Pyrimidine, then it is possible structurally. It is not that Guanine-Uracil is unnatural because it occurs widely specially with RNA's (obviously since uracil is RNA).

Answer 6

Indeed all sorts of deviations occur in base-pairing, there is also "Hoogsteen" type of base-pairing involved in triplex and quadruplex nucleic acids (typically DNA, e.g. telomeric G-quadruplexes).

Answer 7

CORRECT. Hoogsteen is usually taught in biochemistry and not so much in intro to molecular biology or intro to molecular genetics

Answer 8

https://faf.vfu.cz/pub-files/ustavy/ustav-chemickych-leciv/vyuka-predmetu/strukturni-biologie-a-chemie-leciv/dna.pdf

Answer 9

can u help me plz

Answer 10

1. no
2. yes (in RNA)