Which of the following mechanism best describe the manner in which lysozyme lowers the energy required for its substrate to reach its transition state conformation?
A) by binding two molecules and orienting them in a way that favors a reaction between them
B) by altering the shape of the substrate to mimic the conformation of the transition state
C) by speeding up the rate at which water molecules collide with the substrate
D) by binding irreversibly to the substrate so that it cannot dissociate

Explain choice.

Question

Which of the following mechanism best describe the manner in which lysozyme lowers the energy required for its substrate to reach its transition state conformation?
A) by binding two molecules and orienting them in a way that favors a reaction between them
B) by altering the shape of the substrate to mimic the conformation of the transition state
C) by speeding up the rate at which water molecules collide with the substrate 
D) by binding irreversibly to the substrate so that it cannot dissociate

Explain choice.

anonymous · Answer

I say it's B. Because lysozyme causes the substrate molecule to adopt a strained conformation similar to that of the transition state...

anonymous · Answer

I think that's correct : lysozyme breaks down the substrate (peptidoglycans in the cell wall of gram-positive bacteria) by binding the substrate and forcing it into an altered conformation which allows the bond to be broken more easily.