Question

It is observed that 5-10% of the eukaryotic mRNA with multiple AUGs, do not have the 1st AUG as their initiation site. In such cases, the ribosome skips over one or more AUGs before encountering the favourable one and initiating translation. This is postulated to be due to the presence of the following consensus sequences:
CCA CC AUG G
CCG CC AUG G
CCG CC AUG C
AAC GG AUG A
Which of the following sequences sets related to the above postulation is correct?

Answer 1

Perhaps the question is trying to get at the Kozak sequence, which is the recognition sequence for ribosomes for initiation of translation. The concensus sequence is (gcc) gcc Rcc AUGG where R is either guanine or adenine (G or A - a purine). I can't quite make out exactly where the gaps between the options are but if you can you should be able to figure out which one matches the consensus best. (Consensus is just a fancy way of saying the sequence that most mRNA translation initiation sites have). You can read all about it :

http://en.wikipedia.org/wiki/Kozak_sequence