some question
@agreene
u said carcinogen ... i read some thing about oncogene
are they naturally present in our body?? in the inactivated form which later due to some reaction get activated?
oncogenes are cancer causing genes, everyone has lots of them in all their cells. carcinogens are cancer causing molecules (that generally interact with oncogenes). Both are natural in our bodies, we make both, and carcinogens can also come from outside the body--for example tobacco smoke (and any other combustion inhaled) have various carcinogens. The last bit, yes. Those are known as protocarcinogens (there are also proto-oncogenes), proto- comes from the greek (protos, meaning first). These can be activated in many ways through metabolic pathways in digestion, for example. Or by things like phagocytosis by our white blood cells.
I should say, everyone has lots of proto-oncogenes, in that first part
hmm... agree but do dey play any important role in our body i mean if we remove this proto-oncogene is there any side effect?
Well, we don't really know. The Human Genome Project, which first gave us our entire genetic code (for 1 person) didn't happen until recently, I think 1999-2003 (in there somewhere)... So until then, we didn't even know the order of the base pairs... Now we have that, but for most of the genes, we have no idea how they work, or what they do. We have studied a few in detail, like the lac and trp genes, and found that they are WAY more complex than we thought... and in the cause of lac (which lets us digest lactose) the same gene codes for one protein under certain conditions and a different one under other conditions (because of co-activators that change the final protein). On top of not knowing what the genes do... we really don't even know what the proteins do, and we have been studying proteins for much longer. Which is why there are people like me, who are trying to find out what is going on in those genes, and those carcinogens that cause this process...
I have to go for now, but feel free to ask more questions, I'll check this probably in a few hours.
thankyou ... as i have to leave too better next time and thankyou for your possible help
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