Under what conditions does a B dna get converted into a Z dna?? What is the need for this conversion?? Plz rply to this asap.

Question

Under what conditions does a B dna get converted  into a Z dna?? What is the need for this conversion??  Plz rply to this asap.

thomaster · Answer

The conversion of B-DNA to Z-DNA was associated with a ‘flipping over’ of the base pairs so that they had an upside down orientation relative to that of B-DNA. This flipping over resulted both in the production of a syn-conformation in every other base and a change in the deoxyribose-ring pucker in alternate bases. The net result of this reorganization was that the phosphate groups were closer together in Z-DNA than in B-DNA. Hence, under standard cellular conditions, the electrostatic repulsion of these charged phosphate groups would push the molecule into the B-DNA conformation. In the presence of a high-salt solution, the electrostatic repulsion of the phosphate residues is vastly decreased, and Z-DNA becomes the stable conformation. Read more about it here: http://web.mit.edu/lms/www/PDFpapers/Rich_%26_Zhang,_NRG,_7-03.pdf

shrutipande9 · Answer

you are just awesome....thanks alot!!!!!

thomaster · Answer

haha you're welcome :)