Question

A person has a bone fracture and takes a painkiller that causes blood-vessel constriction. Why might this painkiller actually slow bone healing? Specifically describe how the drug would affect the three stages of bone healing.

Answer 1

@Abhisar

Answer 2

Any ideas?

Answer 3

@Somy

Answer 4

Hi Abhisar

Answer 5

Hello @Microrobot

Answer 6

This is a question I had, and I am unable to adequately answer it

Answer 7

I think because the pain killer constricts the vessel it constricts the vessels, process of exchange slows down and thus healing is slowed down.

Answer 8

Specifically describe how the drug would affect the three stages of bone healing.

Answer 9

Is that one part of the question im stuck with

Answer 10

The process of bone fracture healing can be divided into four phases: immediate, early, regenerative, and remodeling. The immediate phase initiates the healing process. The early phase is characterized by inflammation. The regenerative phase occurs when the fracture is bridged with new bone, and the remodeling phase is when the newly generated bone is replaced with mature bone to restore strength and integrity. The early, inflammatory, phase may be critical to successful fracture healing because the chemical signals released during inflammation may be essential in sustaining the healing cascade.

Pain relievers, including COX-2 inhibitors or other NSAIDs achieve their anti-inflammatory effect by inhibiting cyclooxygenase activity, which inhibits prostaglandin synthesis. In addition their, vasoconstriction effect slows down the material exchange. These all results in delayed bone healing

Answer 11

Getting it ?
or i confused you ?

Answer 12

Could you put it in your own words?

Answer 13

kind of sum it up

Answer 14

@Abhisar

Answer 15

Well most of it's part are my own words !
:D

Answer 16

the thing im submiting it has turnitin so it would detect it s plagiarism

Answer 17

To make it simple u can learn that any Non - Steroidal anti inflammatory drug (NSAID) or PAIN KILLERS constricts the vessels of the fractured bone area. This vasoconstriction leads to the reduction of nutrition supply (which is required for healing process). This is the main reason why pain killers slow down the healing process.

Answer 18

Well that's too smartly retarded feature !

Answer 19

Anyways hv i made my point clear ?

Answer 20

Yup

Answer 21

♦ including COX-2 inhibitors
♦inhibiting cyclooxygenase activity, which inhibits prostaglandin synthesis
♦Phases of bone healing

These facts i adopted from various webbies.

Answer 22

Thanks!

Answer 23

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