Question

what is the function of bursa fibricius?

Answer 1

The bursa of Fabricius plays a central role in the development of the antibody‐producing B‐lymphocyte lineage in birds. It consists of more than 10 000 follicles surrounded by connective tissue. These follicles provide an appropriate microenvironment for generating a primary repertoire of antibodies. Immunoglobulin gene diversification is achieved by gene conversion and is antigen independent. Follicular B cells undergo very rapid cell division while expressing several genes also expressed in proliferating germinal centre B cells, such as AID, UNG, Pax5 and Bcl6. Bursal B cell line DT40 provides a unique model system for gene‐targeting studies clarifying the B‐cell development, function and Ig diversification.

Key Concepts:
--Bursa of Fabricius is the primary site for B‐cell development and antibody repertoire formation in birds.

--Antibody diversification in the bursa of Fabricius is antigen independent and occurs mostly by Ig gene conversion.

--Bursal derived DT40 B cell line provides a reverse genetic model to study molecular function of B cells.

Answer 2

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Answer 3

thnks :)

Answer 4

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Answer 5

if bursa of fibricius is involved in the developement of b-lymphocytes... then where from the immmature b lymphocytes come? they r produced from bone marrow?