Question

Can anyone clearly explain the topic... "Regulation of Krebs cycle."

no copies links to be attached please... explain with your knowledge..in the topic..!!

Answer 1

Basically the products of the Krebs Cycle and the metabolic process like ADP, ATP and NADH allosterically inhibit and activate various enzymes. ADP is an allosteric activator because citrate synthase and isocitrate dehydrogenase, which makes sense because ADP is a precursor to ATP, so if we have an excess of it we want to increase the rate of synthesis of ATP to maintain homeostasis. On the other hand, an excess of ATP should cause the metabolic process to slow down, and indeed it does allosterically inhibit citrate synthase, isocitrate dehydrogenase, and alpha-ketogluterate dehydrogenase.

Other intermediary products of the Krebs Cycle also negatively feedback on their production; for instance citrate inhibits citrate synthase, and succinyl-CoA inibits alpha-ketogluterate dehydrogenase. Calcium is another activator, because it is released during increased cellular activity, which requires more ATP.

I know you said no links, but I think this video is pretty helpful:
https://www.khanacademy.org/test-prep/mcat/biomolecules/Krebs-citric-acid-cycle-and-oxidative-phosphorylation/v/regulation-of-krebs-tca-cycle

Answer 2

Thanks @TurningTest ..
It was really very helpful..!!