Question

The pharmaceutical application of Omapatrilat (http://www.bocsci.com/omapatrilat-vanlev-cas-167305-00-2-item-1-340551.html)?

Answer 1

Didn't find much detailed description on the pharmaceutical applications of this chemical, any information will be appreciated.

Answer 2

https://en.wikipedia.org/wiki/Omapatrilat
Omapatrilat (INN) is a novel antihypertensive agent that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme. NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling.
This drug from Bristol-Myers Squibb was not approved by the U.S. Food and Drug Administration due to angioedema safety concerns.[1]
Omapatrilat angioedema was attributed to its dual mechanism of action, inhibiting both angiotensin converting enzyme (ACE), and neutral endopeptidase, both of these enzymes are responsible for the metabolism of bradykinin which causes vasodilation, angioedema, and airway obstruction.
Clinical uses[edit]
The drug was promoted for possible uses in congestive heart failure.

Answer 3

Thanks for your detailed explanation. Very informative!