A humans protease works best at 37 degrees.
What would happen to the enzymes activity at very low temperatures and what happens to the active site in this case?
What would happen to the enzymes activity at very high temperatures, what happens to the active site in this case?

Question

A humans protease works best at 37 degrees. 
What would happen to the enzymes activity at very low temperatures and what happens to the active site in this case? 
What would happen to the enzymes activity at very high temperatures, what happens to the active site in this case?

dean.shyy · Answer

Do you recall the concept of denaturation? If enzymes are subjected to high temperatures, then they are subjected to denaturation. So, if enzymes are denatured, the active sites lose their function and/or shape. On the other hand, a low temperature would only decrease the enzyme's rate of reaction. Think of cold weather. I would assume that the active site on an enzyme does not change from the effects of low temperature. That you would have to double check in your book.

anonymous · Answer

my notebook doesnt mention anything about the active site in regards to temperature and thats what im really confused about :\

dean.shyy · Answer

HIGH TEMPERATURE: Enzyme activity = Increase with high chance to be denatured to be functionless Enzyme active site = Altered with chance that substrate will not fit LOW TEMPERATURE: Enzyme activity = Decrease with chance to be deactivated Enzyme active site = Intact with chance to be deactivated This graphic might help you: http://is.gd/ebMHZU

anonymous · Answer

Well @sandysuliman.I mightbe able to help you out... .. Look we need ti get our basics clear first okay...  Now it is a fact that enzymes require an optimum temperature. So. Enzymes work at their best at 37 degrees.. Now if the temperature is high the enzymes get destroyed.. This is what happens when we fall ill.. Due to high temperatures the enzymes stop functioning properly.. This is why our body temperature must be maintained. Now when the temperature is lowered the enzymes cannot work effectively.. Therefore they begin to work slowly.. So concluding.. This is. Why in winters we wear woollens to protect ourselves and maintain our body temperatuw... Hope this wilk clear

anoop27 · Answer

at low temp enzyme freezes so they are not able to perform their function and high Temp Enzyme Denatured (Enzymes are Proteineous in nature)

anonymous · Answer

Either case, it will cause the protein to unfold in its secondary structure, making it inactive. This is called denaturation.