Question

what are the consequences of muscle death at the thigh region?

need some ideas ? just throw in your thoughts.

Answer 1

Uh, you probably wouldn't be able to walk much anymore.

Answer 2

what else just give me more of your ideas @InYourHead

anything that comes to mind

Answer 3

lets think on the like of myoglobin production

Answer 4

If the muscle were to die off very quickly, it could cause blood poisoning.

Answer 5

Depends on how quickly the cells die, and how many of them die.

Answer 6

that is what i am talking about @InYourHead

Answer 7

what poisoning occurs specofics @InYourHead

Answer 8

Another Q What are the most common conditions from smoking?

Answer 9

Sepsis. That's what we call blood poisoning.

If a large number of cells die, they should be removed. Otherwise, they could become a breeding ground for bacteria. Those bacteria could poison the blood, and spread to vital organs, like the brain and the heart.

Answer 10

Most common conditions for smoking? Emphysema. Maybe lung cancer.

Answer 11

septicemia of course is normal but i want a myoglobin related answer @InYourHead

Answer 12

emphysema and ? before lung cancer

Answer 13

I'm not sure what you want to know about how muscle cell death relates to myoglobin.
Dead cells obviously don't have any use for myoglobin.

Emphysema is where the air sacs in our lungs are destroyed.
It makes it so that our lungs take in less air.
If it gets bad, it could damage our other vital organs, because they don't get enough oxygen.

Answer 14

there is some link to myoglobin @InYourHead just please find out and explain it better to me i plead

Answer 15

You know what myoglobin is, right?
It's a protein that helps our muscle cells hold oxygen.

Myoglobin is produced in living muscle cells.
Dead muscle cells don't produce myoglobin, because they're dead.

Do you know what else you're looking for?

Answer 16

that is it you gave the answer

when it is death what happens to that tissue and which areas does it poison first

Answer 17

If a lot of thigh muscle cells die, the cells can block blood vessels, and cause the death to spread across the body, starting with the thigh.

If bacteria enter the bloodstream from there, they could poison any part of the body. I don't think they follow a specific order.

Normally, when cells die, they're eaten by special white blood cells, called "macrophages."
The dead cells are eventually removed from our bodies, through our digestive system.

But when too many cells die, the macrophages can't keep up. They have trouble doing their jobs.

Answer 18

Kidney failure at max!

Answer 19

Death of muscle cells (rhabdomyolysis) will release a lot of myoglobin. this released myoglobin is toxic to the renal tubular epithelium so it can cause acute kidney failure.
In my clinical chemistry class we use myoglobin as an indication for muscle injury like heart attack.

Answer 20

Hm! I didn't know that myoglobin would remain intact after the cell had died. Thanks.

Answer 21

kidney failure us one of the best ideas @DocNomi

Answer 22

@themaster excellent one too

Answer 23

kidney failure is what i was looking for i still need to know exactly what happens in that kidney @themaster @DocNomi

Answer 24

Once the myoglobin molecule is filtered by the glomerulus it enters the proximal tubular cells and is taken up by lysomes at acid pH. The heme pigment then splits into its globulin and ferrihemate components. Ferrihemate is transported out of the tubular cell at the expense of ATP. The tubular cell, thus is injured due to renal ischemia, hypoxia and a critical reduction of ATP stores.

Answer 25

and this is the reference for the stated answer by thomaster
Knockel JP. Pigment nephropathy. In: primer on kidney diseases, Greenberg A. (ed). Academic Press New York 1998;273­-6.
you may also want to see
Zager RA. Heme protein ischemic interactions at the vascular, intraluminal and renal tubular cell levels: implications for therapy of myoglobin-induced renal injury. Ren FaiI1992;l4:341-4.
Brady HR, Brenner BM. Acute renal failure; in Harrison's Principles of Internal Medicine 14th Edition, McGraw Hill, New York 1998:507.

Answer 26

Yes thanks i did forget to mention the refs :P

Answer 27

thanks @themaster and @DocNomi