Question

Consider the structures of HME and histidine, then predict what the relative pKas of the -amino groups are in these two compounds and briefly explain your comparison

Answer 1

histidine is basic, polar.

Answer 2

so whats the pka of their alpha amino groups?, i thought they were both polar

Answer 3

What do you mean by HME?

Answer 4

histidine methyl ester

Answer 5

i don't know the pKa, i am sure you can find their properties online. On wikipedia, the pKa of histidine says 6.0, by adding a methyl group, you make it more basic.

Answer 6

its only asking the pka of their amine groups and if they are the same

Answer 7

and why

Answer 8

Different structures, different values.