Consider the structures of HME and histidine, then predict what the relative pKas of the -amino groups are in these two compounds and briefly explain your comparison

Question

abb0t · Answer

histidine is basic, polar.

anonymous · Answer

so whats the pka of their alpha amino groups?, i thought they were both polar

abb0t · Answer

What do you mean  by HME?

anonymous · Answer

histidine methyl ester

abb0t · Answer

i don't know the pKa, i am sure you can find their properties online. On wikipedia, the pKa of histidine says 6.0, by adding a methyl group, you make it more basic.

anonymous · Answer

its only asking the pka of their amine groups and if they are the same

anonymous · Answer

and why

abb0t · Answer

Different structures, different values.