Question

what is gelsolin? how does it actually help in movement of cell?

Answer 1

-Pay no attention just marking this question so I can come back to it later.-

Answer 2

Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency.[1] Gelsolin is located intracellularly (in cytosol and mitochondria) and extracellularly (in blood plasma)

Answer 3

Idk how it helps xD

Answer 4

it did help a little thnx:)

Answer 5

@abb0t help please

Answer 6

Yes, dwagonslaya has it correct. It is a protein. Hence, the suffix "in" usually indicates protein.

As far as movement of the cell? What do you mean by that? Cells do not move, unless it is unicellular, such as an amoeba.

Answer 7

the amoeboid movement of cell along the substratum

Answer 8

I don't think this protein aids in any movement. It aids in making the mitochondrial membrane more permeable. That's all I know.

Answer 9

for eg during wound heling the cells crawl and occupy the spaces where the tearing of epithelium occurs.

Answer 10

*healing

Answer 11

I forgot to add that xD

Answer 12

I really do not know. I am not familiar with this protein. What course is this for? Maybe @aaronq may know?

Answer 13

The actin-binding protein gelsolin is involved in remodeling the actin cytoskeleton during growth-factor signaling, apoptosis, cytokinesis, and cell movement. Calcium-activated gelsolin severs and caps actin filaments. The 3.4 angstrom x-ray structure of the carboxyl-terminal half of gelsolin (G4-G6) in complex with actin reveals the basis for gelsolin activation. Calcium binding induces a conformational rearrangement in which domain G6 is flipped over and translated by about 40 angstroms relative to G4 and G5. The structural reorganization tears apart the continuous beta sheet core of G4 and G6. This exposes the actin-binding site on G4, enabling severing and capping of actin filaments to proceed.

Answer 14

Hope that helps!

Answer 15

i haven't come across this protein in my studies. But i can look into if you really need to know.

Answer 16

actually i was studying cytoskeletons. on which i have to give a presentation tomo. this is the part where i am stuck. @dwagonslaya420 ty.

Answer 17

Np

Answer 18

ty u soooo much guys @aaronq @abb0t @dwagonslaya420
i finally found it in my book. pheww...:)

Answer 19

good stuff !

Answer 20

maybe post it here, so we can all know about it?

Answer 21

yes yes sure....give me 2 mins

Answer 22

Yes, I'll put it in my notes!

Answer 23

btw was I close to the answer? xD

Answer 24

for controlling actin polymerization there are actin binding proteins out of which gelsolin is one.
during amoebid movement of cells the cytosol flows forward like a gel, this sol to gel transformation depends on assembly of new actin filaments in front part of moving cell and disassembly of old actin filament in rear part. this requires the assistance of severing protein gelsolin.

Answer 25

it is thought to break the actin filament and then it remains bound to the positive end of resulting fragment where it prevents addition or exchange of actin subunits. the negativ ends reapidly reduce. this causes disintegration in the rear part while the actin monomers get added to the positive end in the front part. this assists the movement of cells.

Answer 26

@dwagonslaya420 you were pretty close.

Answer 27

Dang I was like 2 sentences off
I missed the 2-3 key points

Answer 28

yes...pretty close. good going @dwagonslaya420 :)

Answer 29

nice, thanks for the info.