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Chemistry 22 Online
OpenStudy (anonymous):

what is the function of NADPH in Photosynthesis, i know it can help to product organic molecules, but how it works?

OpenStudy (australopithecus):

NADPH is a reducing agent, also known as an electron transporter, it essentially gets oxidized to NADP+, which results in the release of energy. It is formed in the last step of the calvin cycle, it is also formed in the pentophosphate pathway (an alternative pathways to the TCA cycle) It works just like NADH and FADH2 it as a way of transfering energy According to Hess's law reactions can be coupled together, enzymes can help to coupling the oxidiation of NADP+ to other otherwise unfavourable reactions to make them proceed forword

OpenStudy (australopithecus):

Does that help or do you want to know exactly how NADP+ is higher energy than NADPH

OpenStudy (australopithecus):

http://dehydrogenase.co.uk/NADP/nadp-01.png The image depicts the formation of NADPH from NADP+ as you can see NADPH has a high energy phosphate bond that it essentially loses when it is oxidized to NADP+ resulting ina free phosphate forming and energy being released.

OpenStudy (australopithecus):

You can also kind of think of it as ATP and GTP although ATP and GTP carry significantly more chemical potential energy than the electron transporters.

OpenStudy (australopithecus):

oops made a mistake, "According to Hess's law reactions can be coupled together, enzymes can help to coupling the oxidiation of NADPH to other otherwise unfavourable reactions to make them proceed forword"

OpenStudy (australopithecus):

oops I messed up NADPH is oxidized in the last step of the cori cycle

OpenStudy (australopithecus):

http://www.uic.edu/classes/bios/bios100/f05pm/calvin.jpg Cori Cycle

OpenStudy (australopithecus):

Is my explanation helping at all?

OpenStudy (australopithecus):

blah Im all over the place that is the calvin not the cori lol

OpenStudy (australopithecus):

But essentially, NADPH -> P + NADP+ + Energy

OpenStudy (australopithecus):

The body stores energy in chemical bonds in molecules

OpenStudy (australopithecus):

If you wondering how the body can couple these reactions it has to do with how enzymes can help to coordinate molecules together pushing equilibrium forward. Not that I'm saying that enzyme increase the amount of product you acquire at equilibrium! No enzyme can do this, they simply increase the speed at which you reach equilibrium (increasing the rate of the reaction)

OpenStudy (australopithecus):

well actually stabalizing the transition state is a big factor as well in enzymes ability to catalyze reactions

OpenStudy (anonymous):

does the NADPH release the P to help some enzyme to process the calvin cycle and acts as a kinds of allosteric regulation that amplify enzyme activity

OpenStudy (anonymous):

am i right?

OpenStudy (australopithecus):

Blahhhh everything I wrote I lost lol

OpenStudy (australopithecus):

Essentially what is happening is the last step is NADPH is transfering a phosphate group 3-phosphoglycerate, this is often done as a way of transfering energy to the substrate so that the breaking of the phosphate group off can fuel another chemical transformation of it

OpenStudy (australopithecus):

Im not sure you are correct about the regulation tbh Im not too familure with the calvin cycle. If you are very interested in its regulation you should look up a review paper on it, wikipedia seems to have a decent outline of it as well

OpenStudy (anonymous):

tks, i will do it. XD

OpenStudy (australopithecus):

NADPH is mainly formed in the pentose phosphate pathway though from my knowledge

OpenStudy (australopithecus):

there are probably regulating factors that keep the pathway from running in reverse though

OpenStudy (anonymous):

tk u very much. English is not my first language so it's a little difficult for me to learn biology(my biology textbook is wrote in English) @^@

OpenStudy (australopithecus):

Well yeah english is the official language of science, I'm sure you can find some reasources in your native language as well if you look hard enough. I think the best way to work with these pathways is to learn about every enzyme involvd in the pathway individual and what affects it. Essentially write a story.

OpenStudy (australopithecus):

individually*

OpenStudy (australopithecus):

you should check out "molecular biology of the cell", it is a pretty good text book for this stuff

OpenStudy (anonymous):

actually im reviewing this part XD

OpenStudy (anonymous):

tk u again ………………^^

OpenStudy (australopithecus):

http://i.imgur.com/q1mh4AA.png

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