Question

Curiosity
Immune system, Cancer and HIV

Answer 1

Ok
so my question 1 is
Why is it that sometimes our immune system is able to kill HIV virus? mostly its rare but it does happen?

Answer 2

@shrutipande9 @Abhisar @Frostbite

Answer 3

when it comes to virus
immune system can actually be taken over By virus, so how is it that its still possible that our immune system actually kills viral cells
i kinda get it that this job is done by T cytotoxic cells but still if it Can kill the virus, why is it so rare? Why T cytotoxic cells are not straightaway activated? like always in such cases i mean

Answer 4

im so sorry for taking your time T_T @Frostbite

Answer 5

Okay let's get rid of the most obvious: "You can't die from HIV"
HIV, standing for Human Immunodeficiency Virus, are targeting different immune cells among others the T-cells who are the very foundation for the antigen recognition. So basically if they are getting killed, we can't get any kind of antibodies to help them fight the infection.

Furthermore it is known that HIV is being very effective and it replicate very fast. It only take one virus to infect a cell, but it release upon lysis way more.
The only thing we actually got to fight the virus is the macro-phages (This is just a guess), which is not even that effective.

Answer 6

i know this actually

Answer 7

the question is if now all immune system is basically taken over
how come HIV just disappears so suddenly ?

Answer 8

i mean ive heard about the cases where the person had HIV but he doesn't have it anymore

Answer 9

Hmmm it could be protases.

Answer 10

i know about dormant state of the virus at which u cannot detect the presence of HIV

Answer 11

protases?

Answer 12

That is currently one of the ways we are fighting HIV we knock out the HIV-1 protase. It is required by HIV in order to replicate. Without it you can hold down HIV forever.

Answer 13

Protases are enzymes that catalyze the cleavage of proteins.

Answer 14

so u mean our body does this on its own at times?

Answer 15

It could be, I personally is not into HIV research, but a lot of my collages are. Usually I would say no, that it is not possible in the way you say it. The protase would usually cleavage the HIV-1 protase upon first infection.

I just make a super widespread guess and say mutations?

Answer 16

I don't know if HIV is undergoing proof reading.

Answer 17

tbh when i was learning immune and about diseases this question just kinda popped up in my mind and now im just wondering how is that

Answer 18

but even if we say that protase job is done by our body itself
then why doesn't it always happen

Answer 19

weird kinda

Answer 20

When you say always, you mean between different people or in same cell line?

Answer 21

i mean different people

Answer 22

why is it in some ppl this 'job' or whatever it is called is activated but not is some other people

Answer 23

That in fact I can't answer. I am only guessing, and I'm not up to date with the newest knowledge about HIV. I am only work very little in silico with HIV-1 protase.

I suggest you try read some reviews from some of the scientific journals. Hard literature, but you should be able to overcome it, else ask can we can't be able to answer that specific part from the news literature in HIV research.

Answer 24

hmmmm

Answer 25

right, i guess i should do so, it was just curiosity so i wanted to know what other ppl think, and is it that only im wondering about it? hmmm

Answer 26

@thomaster @nincompoop

Answer 27

this is just what i think.....just my speculation...see during infection the first phase is viral replication phase in the peripheral blood. if the immune cells act on d virus before it replicates and is present in huge no..then probably it can happen....this is an absolute random reasoning...no scientific proof attached

Answer 28

i was thinking about this also
but it still kinda doesn't prove hmmm

Answer 29

yeah now i am curious to know....

Answer 30

welcome to my club lol @shrutipande9

Answer 31

hahah..lol

Answer 32

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Answer 33

the hell lol

Answer 34

Rainbow LOL

Answer 35

crazy @Abhisar with LOL immune system

Answer 36

:D

Answer 37

xD

Answer 38

What was ur question regarding cancer ?

Answer 39

im gonna ask it after this question is cleared, it's pretty similar tho

Answer 40

ok

Answer 41

Where did u read this "immune system is able to kill HIV virus" ?

Answer 42

i know it

Answer 43

it does happen
tho its rare

Answer 44

question is How if it does?
and Why not always?

Answer 45

Actually what u read is partially correct !

Answer 46

HIV infects kills CD4+ T cells and incorporate their genetic material into it. By this they use to replicate their genome using host cell's machinery. Gradually they kill the CD4+ T cells as their life cycle is Lytic.

Answer 47

*infects and Kills

Answer 48

Now what happens is that our body tries to fight against the HIV infected cells mainly by non specific immunity like interferons.

Answer 49

Our immune systems also use specific immunity like CD8+ T cells to kill off the HIV-infected CD4+ T cells.

Answer 50

ok this is a thing

Answer 51

But unfortunately they can not eliminate HIV from the body. Over a period of time, HIV infection exhausts the body’s immune defenses. This leaves HIV-infected people vulnerable to a variety of other infections.

Answer 52

But there are cases

Answer 53

okay supposed the one that kills HIV are interferons.

Answer 54

again same question
WHY doesn't it always happen?

Answer 55

It happens most of the time

Answer 56

why does it happen in some people but not in others

Answer 57

Like ??

Answer 58

This happens always, untill there is some issue with the immune system

Answer 59

The same process is for common cold

Answer 60

got it ?

Answer 61

i think u kinda don't get my question....

Answer 62

what xactly u want to know ?

Answer 63

read the whole discussion

Answer 64

Were did u read this...dissapearing of HIV ?

Answer 65

I guess
when it comes to virus
immune system can actually be taken over By virus, so how is it that its still possible that our immune system actually kills viral cells
i kinda get it that this job is done by T cytotoxic cells but still if it Can kill the virus, why is it so rare? Why T cytotoxic cells are not straightaway activated? like always in such cases i mean

This is ur main dilemma

Answer 66

is it ?

Answer 67

yeah kinda

Answer 68

ohkay lets interact..!!

Answer 69

What do u mean by immune system can actually be taken over By virus ?

Answer 70

???

Answer 71

well you do know that urself

Answer 72

Virus turns immune system cells to viral cells of its own type basically saying

Answer 73

yes and it occurs gradually one cell at a time, initially when virus starts infecting the T cells there are some functional t cells left. These left T cells try to kill the infected T cells. And they do kill but are not able to prevent the infection from spreading since the rate of multiplication is much faster

Answer 74

one thing to be noted that is T cells kill the INFECTED CELLS and not the virus itself

Answer 75

I don know wthr i am reaching to ur doubt or not !

Answer 76

u there ?

Answer 77

yeah here

Answer 78

well i do know this also

Answer 79

wait

Answer 80

are u saying that if Cytotoxic cells were to kill the infected cell
it would only kill the cell and not the virus inside it?

Answer 81

No No

Answer 82

good
cuz i was ready to argue lmao

Answer 83

actually now i know what do u want to know :D

Answer 84

good boy i think u finally got me

Answer 85

r u really typing smthng ?

Answer 86

So why on earth Killers (T cytotoxic cells) do not wake up on time to wipe off damn Vampires (viruses) from our body?

Answer 87

See actually ur question is valid

Answer 88

and if its not T killer cells, then WHAT on earth kills HIV virus sooooo rarely
that u can barely find a case where it happened and we call it 'miracle'

Answer 89

i mean i do believe in miracles, but there is a way it happens right?

Answer 90

Actually viral protein vpu is created by HIV during infection. This directly interferes with the immune response protein IRF3 to dampen the ability of the immune system to protect against virus infection.

Answer 91

There is an ongoing research on it, Scientists have found that HIV strains engineered to lack vpu, did not impair the immune response.

Answer 92

btw IRF3 is a kind of interferon regulatory transcription factor

Answer 93

so does my curiosity make sense?

Answer 94

yes, i think if somebody survised HIV infection "so called miracle". It might be possible due to a mutated HIV strain infection (EXTREME RARE, MATTER OF CHANCE) which lacked VPU

Answer 95

*survived

Answer 96

itna sannata kyu hai bhai ??

Answer 97

kyunki abhi maine bolna chalu nahi kiyaXD
mai sirf sun rahi hu