Okay I have a question, so I have two different colored eyes also known as heterochromia iridum and I was wondering what are the chances of my children having two different colored eyes? A lot of websites say its hereditary but is it something that skips a generation or? I don't know. I am just curious of the likelihood of my future children having this mutation?

Question

shreehari499 · Answer

Hmm..Hey! @oliviacaroline2123 ! 
U there?

shreehari499 · Answer

Anyways..the specific disease that you're speaking of is an Autosomal Dominant Trait

shreehari499 · Answer

Is your husband Affected? or not ? so that i can draw the Pedigree Chart and find out the probability of your children being affected from it. :)

anonymous · Answer

@shreehair499 Lets say my nonexistent husband didn't have it, what would be the probability then? and thank you for helping me! :)

shreehari499 · Answer

Consider you to be X^cX^c (affected) and your husband XY(normal)

shreehari499 · Answer

C for heterochromatia iridium

shreehari499 · Answer

So crossing X^cX^c with XY we get X^cX , X^cY , X^cX and X^cY

shreehari499 · Answer

So this shows that both your daughters will not be affected, instead they will be carriers, buy both sons will be affected with the disease

shreehari499 · Answer

*but

anonymous · Answer

@Shreeehari499 That kind of makes sense but also how does gender affect it?

shreehari499 · Answer

Yeah gender does come into play... Suppose your husband is affected, the probability for all your children to be affected will be 100% I.e all boys and girls become affected

anonymous · Answer

You first said it was an autosomal dominant trait and then calculated probabilities as if it were a sex linked recessive trait? @shreehari499

Futhermore, it is not even always autosomal recessive, we need far more details to predict with reasonable accuracy anything about the offspring of @OliviaCaroline2123

It would be best for you if you talked about this to a genetic councelor now, or once you have a husband.

abhisar · Answer

Hehe, as niel said it's not so simpe, $Heterochromia~iridum$ is basically a class of disorder in which both eyes appear to have different color. It may be congenital or may be acquired. In case it is congenital, may be due to dominant, or in most cases may be a polygenic effect. it can also due to neurological disorders like in the case of weber syndrome.

shreehari499 · Answer

*scratching head* Yeah right! I was wrong :)

anonymous · Answer

no problem