6. The oxidation of malate by NAD+ to form oxaloacetate is a highly endergonic reaction under standard conditions (G’o = +7.0 kcal/mol). The reaction proceeds readily under physiological conditions:
(b) Assuming an [NAD+]/[NADH] ratio of 8 and a pH of 7, what is the lowest [malate]/[oxaloacetate] ratio at which oxaloacetate can be formed from malate?

Question

6.	The oxidation of malate by NAD+ to form oxaloacetate is a highly endergonic reaction under standard conditions (G’o = +7.0 kcal/mol).  The reaction proceeds readily under physiological conditions:
(b)	Assuming an [NAD+]/[NADH] ratio of 8 and a pH of 7, what is the lowest [malate]/[oxaloacetate] ratio at which oxaloacetate can be formed from malate?

anonymous · Answer

whats the question??

jthec · Answer

what is the lowest [malate]/[oxaloacetate] ratio at which oxaloacetate can be formed from malate?

caozeyuan · Answer

Ok so this is equilibrium question

caozeyuan · Answer

$$K=\frac{ \left[ oxaloacetate \right] \left[ NADH\right] }{ \left[ malate \right] \left[ NAD ^{+}\right]  }$$

caozeyuan · Answer

you want K>=1 so that action proceed to the right

jthec · Answer

yeah

caozeyuan · Answer

[NAD+]/[NADH]=8 so for K to be 1, [malate]/[oxaloacetate] should be 1/8